Yeast histone H3 and H4 amino termini are important for nucleosome assembly in vivo and in vitro: redundant and position-independent functions in assembly but not in gene regulation.

@article{Ling1996YeastHH,
  title={Yeast histone H3 and H4 amino termini are important for nucleosome assembly in vivo and in vitro: redundant and position-independent functions in assembly but not in gene regulation.},
  author={Xiao Ling and Troy A. A. Harkness and Michael Schultz and G Fisher-Adams and Michael R. Grunstein},
  journal={Genes & development},
  year={1996},
  volume={10 6},
  pages={686-99}
}
The hydrophilic amino-terminal sequences of histones H3 and H4 extend from the highly structured nucleosome core. Here we examine the importance of the amino termini and their position in the nucleosome with regard to both nucleosome assembly and gene regulation. Despite previous conclusions based on nonphysiological nucleosome reconstitution experiments, we find that the histone amino termini are important for nucleosome assembly in vivo and in vitro. Deletion of both tails, a lethal event… CONTINUE READING
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