Yeast genes involved in cadmium tolerance: Identification of DNA replication as a target of cadmium toxicity.

@article{Serero2008YeastGI,
  title={Yeast genes involved in cadmium tolerance: Identification of DNA replication as a target of cadmium toxicity.},
  author={Alexandre Serero and J Castro Lopes and Alain Nicolas and S. Boiteux},
  journal={DNA repair},
  year={2008},
  volume={7 8},
  pages={1262-75}
}
Cadmium (Cd(2+)) is a ubiquitous environmental pollutant and human carcinogen. The molecular basis of its toxicity remains unclear. Here, to identify the landscape of genes and cell functions involved in cadmium resistance, we have screened the Saccharomyces cerevisiae deletion collection for mutants sensitive to cadmium exposure. Among the 4866 ORFs tested, we identified 73 genes whose inactivation confers increased sensitivity to Cd(2+). Most were previously unknown to play a role in cadmium… CONTINUE READING
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