Yeast flavohemoglobin is an ancient protein related to globins and a reductase family.

@article{Zhu1992YeastFI,
  title={Yeast flavohemoglobin is an ancient protein related to globins and a reductase family.},
  author={Haisun Zhu and Austen F. Riggs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 11},
  pages={5015-9}
}
The hemoglobin of yeast is a two-domain protein with both heme and flavin prosthetic groups. The nucleotide sequences of the cDNA and genomic DNA encoding the protein from Saccharomyces cerevisiae show that introns are absent and that both domains are homologous with a flavoheme protein from Escherichia coli. The heme domains are also homologous with those of O2-binding heme proteins from several other distantly related bacteria, plants, and animals; all appear to be members of the same globin… CONTINUE READING

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