Yeast dsRNA viruses: replication and killer phenotypes.

  title={Yeast dsRNA viruses: replication and killer phenotypes.},
  author={Donald J Tipper and Manfred J. Schmitt},
  journal={Molecular microbiology},
  volume={5 10},
The cytoplasmic L-A dsRNA virus of Saccharomyces cerevisiae consists of a 4.5 kb dsRNA and the two gene products it encodes; the capsid (cap) and at least one copy of the capsid-polymerase (cap-pol) fusion protein. Virion cap-pol catalyses transcription of the plus (sense)-strand; this is extruded from the virus and serves as messenger for synthesis of cap and cap-pol. Nascent cap-pol binds to a specific domain in the plus strand to initiate encapsidation and then catalyses minus-strand… CONTINUE READING

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