Yeast cytochrome c peroxidase: mechanistic studies via protein engineering.

  title={Yeast cytochrome c peroxidase: mechanistic studies via protein engineering.},
  author={James E. Erman and Lidia B. Vitello},
  journal={Biochimica et biophysica acta},
  volume={1597 2},
Cytochrome c peroxidase (CcP) is a yeast mitochondrial enzyme that catalyzes the reduction of hydrogen peroxide to water by ferrocytochrome c. It was the first heme enzyme to have its crystallographic structure determined and, as a consequence, has played a pivotal role in developing ideas about structural control of heme protein reactivity. Genetic engineering of the active site of CcP, along with structural, spectroscopic, and kinetic characterization of the mutant proteins has provided… CONTINUE READING

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