Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.

@article{Glowczewski2004YeastCA,
  title={Yeast chromatin assembly complex 1 protein excludes nonacetylatable forms of histone H4 from chromatin and the nucleus.},
  author={Lynn Glowczewski and Jakob Harm Waterborg and Judith G Berman},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 23},
  pages={10180-92}
}
In yeast, the establishment and maintenance of a transcriptionally silent chromatin state are dependent upon the acetylation state of the N terminus of histone proteins. Histone H4 proteins that contain mutations in N-terminal lysines disrupt heterochromatin and result in yeast that cannot mate. Introduction of a wild-type copy of histone H4 restores mating, despite the presence of the mutant protein, suggesting that mutant H4 protein is either excluded from, or tolerated in, chromatin. To… CONTINUE READING
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