Yeast centromere DNA is in a unique and highly ordered structure in chromosomes and small circular minichromosomes.

@article{Bloom1982YeastCD,
  title={Yeast centromere DNA is in a unique and highly ordered structure in chromosomes and small circular minichromosomes.},
  author={Kerry S. Bloom and John R Carbon},
  journal={Cell},
  year={1982},
  volume={29 2},
  pages={305-17}
}
We have examined the chromatin structure of the centromere regions of chromosomes III and XI in yeast by using cloned functional centromere DNAs (CEN3 and CEN11) as labeled probes. When chromatin from isolated nuclei is digested with micrococcal nuclease and the resulting DNA fragments separated electrophoretically and blotted to nitrocellulose filters, the centromeric nucleosomal subunits are resolved into significantly more distinct ladders than are those from the bulk of the chromatin. A… CONTINUE READING
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