Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential for endoplasmic reticulum-to-Golgi protein traffic.

@article{Duden1994YeastBA,
  title={Yeast beta- and beta'-coat proteins (COP). Two coatomer subunits essential for endoplasmic reticulum-to-Golgi protein traffic.},
  author={Rainer Duden and Midori Hosobuchi and Susan T. Hamamoto and Mark Winey and Breck Byers and Randy Schekman},
  journal={The Journal of biological chemistry},
  year={1994},
  volume={269 39},
  pages={24486-95}
}
To understand better the role of non-clathrin coat proteins in membrane traffic, we have cloned and characterized two essential genes encoding subunits of the yeast coatomer, SEC26 and SEC27. Sec26p is a 109-kDa protein that shares 43% sequence identity with mammalian beta-coat protein (beta-COP). Sec26p-depleted cells accumulate endoplasmic reticulum (ER) forms of secretory precursor proteins, and growth ceases after a dramatic accumulation of ER membranes. Sec26p overproduction partially… CONTINUE READING
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