Yeast at the Forefront of Research on Ageing and Age-Related Diseases.

  title={Yeast at the Forefront of Research on Ageing and Age-Related Diseases.},
  author={Bel{\'e}m Sampaio-Marques and William C. Burhans and Paula Ludovico},
  journal={Progress in molecular and subcellular biology},
Ageing is a complex and multifactorial process driven by genetic, environmental and stochastic factors that lead to the progressive decline of biological systems. Mechanisms of ageing have been extensively investigated in various model organisms and systems generating fundamental advances. Notably, studies on yeast ageing models have made numerous and relevant contributions to the progress in the field. Different longevity factors and pathways identified in yeast have then been shown to… 

Stress and ageing in yeast.

The cellular processes that are involved in alleviating the effects of stress on ageing are considered, together with the possible role of early stress events on subsequent ageing of cells.

Effect of Caloric Restriction on Aging: Fixing the Problems of Nutrient Sensing in Postmitotic Cells?

It has been suggested that affecting nutritional sensors (e.g., AMPK) in postmitotic cells might improve the state of the entire multicellular organism, slow down its aging, and increase the lifespan.

Yeast as a Model to Find New Drugs and Drug Targets for VPS13-Dependent Neurodegenerative Diseases

Findings point at areas for further investigation in a higher eukaryotic model of VPS13-related diseases and to new therapeutic targets: calcium signalling and copper and iron homeostasis, and the identified drugs are interesting candidates for drug repurposing for these diseases.

Systematic identification of yeast mutants with increased rates of cell death reveals rapid stochastic necrosis associated with cell division

The results suggest that rapid stochastic necrosis during cell division is a common type of cell death resulting from the dysfunction of different genes, and that this type of death seems to have a common proximal cause which might be related to the properties of the cell wall and/or plasma membrane.

Discovery of fifteen new geroprotective plant extracts and identification of cellular processes they affect to prolong the chronological lifespan of budding yeast

It is provided evidence that the fifteen geroprotective plant extracts exhibit partially overlapping effects on a distinct set of longevity-defining cellular processes that significantly extend the longevity of chronologically aging yeast not limited in calorie supply.

PCK1 Deficiency Shortens the Replicative Lifespan of Saccharomyces cerevisiae through Upregulation of PFK1

It is suggested that PCK1 deficiency enhanced the ROS level and shortened the RLS of S. cerevisiae via PFK1, one of the most upregulated genes, which was involved in the glycolysis process and ROS generation.

Life-span extension by pigmented rice bran in the model yeast Saccharomyces cerevisiae

Using yeast model, extract and bioactive compounds, quercetin and protocatechuic acid found in the rice bran pericarp, effectively reduced levels of intracellular reactive oxygen species (ROS), restored plasma membrane damages and prolonged life-span of pre-treated wild-yeast cells.

Propagation of Mitochondria-Derived Reactive Oxygen Species within the Dipodascus magnusii Cells

Mitochondria fragmentation was found to be primarily induced by mitochondrial ROS preceding the generalized oxidative stress development, and prooxidant-induced oxidative stress was initiated in mitochondria, far preceding the appearance of generalized oxidative Stress in the whole cell.

Mitochondrial Dysfunctions May Be One of the Major Causative Factors Underlying Detrimental Effects of Benzalkonium Chloride

The data showed that BAC acts adversely on cell bioenergetics (especially on ATP synthesis and mitochondrial dynamics) and that its prooxidant effect can be partially prevented by the mitochondria-targeted antioxidant SkQ1.



Exploring the power of yeast to model aging and age-related neurodegenerative disorders

Different aging theories, common cellular pathways driving aging and neurodegenerative diseases and the major contributions of yeast to the state-of-art knowledge in both research fields are reviewed.

The role of autophagy in the regulation of yeast life span

It is demonstrated that yeast remains an invaluable tool for the identification and characterization of conserved mechanisms that promote cellular longevity and are likely to be relevant to humans, and that the process of autophagy has been implicated in nearly all known longevity‐promoting manipulations and thus represents an ideal target for interventions aimed at improving human health span.

Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing

Recent findings are described that shed light on how longevity pathways and metabolic status impact maintenance of the proteome in both yeast ageing paradigms and demonstrate that yeast remain a powerful model system for elucidating these relationships and their influence on ageing regulation.

Yeast models of Parkinson's disease-associated molecular pathologies.

Harnessing the power of yeast to unravel the molecular basis of neurodegeneration

How yeast models are adding to the current understanding of several neurodegenerative disorders is summarized, with a focus on the simple and well‐characterized eukaryote Saccharomyces cerevisiae.

Lessons on longevity from budding yeast

The past decade has seen fundamental advances in understanding of the ageing process and raised optimism that interventions to slow ageing may be on the horizon, and studies of budding yeast have resulted in some of the best candidates for anti-ageing drugs currently in development.

Yeast as a Model for Alzheimer's Disease: Latest Studies and Advanced Strategies.

This review chapter focuses on the considerable progress made using S. cerevisiae as a model system for Alzheimer's disease, which combines well-established, fast genetic and molecular techniques with the ability to faithfully capture key molecular aspects of neurodegeneration.

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

The identification of multiple novel effectors of yeast chronological lifespan will greatly aid in the elucidation of mechanisms that cells and organisms utilize in slowing down the aging process.

Budding yeast as a model organism to study the effects of age.

The possible mechanisms allowing old cells to produce rejuvenated progeny are described in terms of accumulation and inheritance of aging factors and how changes in different organelles might interplay with each other are described.