Yeast actin cytoskeleton mutants accumulate a new class of Golgi-derived secretary vesicle.

@article{Mulholland1997YeastAC,
  title={Yeast actin cytoskeleton mutants accumulate a new class of Golgi-derived secretary vesicle.},
  author={Jon Mulholland and A Wesp and Howard Riezman and David Botstein},
  journal={Molecular biology of the cell},
  year={1997},
  volume={8 8},
  pages={
          1481-99
        }
}
Many yeast actin cytoskeleton mutants accumulate large secretory vesicles and exhibit phenotypes consistent with defects in polarized growth. This, together with actin's polarized organization, has suggested a role for the actin cytoskeleton in the vectorial transport of late secretory vesicles to the plasma membrane. By using ultrastructural and biochemical analysis, we have characterized defects manifested by mutations in the SLA2 gene (also known as the END4 gene), previously found to affect… CONTINUE READING

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