Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking.

@article{BelgarehTouz2002YeastVA,
  title={Yeast Vps55p, a functional homolog of human obesity receptor gene-related protein, is involved in late endosome to vacuole trafficking.},
  author={Na{\"i}ma Belgareh-Touz{\'e} and Sandrine Avaro and Yves Rouill{\'e} and Bernard Hoflack and Rosine Haguenauer-Tsapis},
  journal={Molecular biology of the cell},
  year={2002},
  volume={13 5},
  pages={1694-708}
}
The Saccharomyces cerevisiae VPS55 (YJR044c) gene encodes a small protein of 140 amino acids with four potential transmembrane domains. VPS55 belongs to a family of genes of unknown function, including the human gene encoding the obesity receptor gene-related protein (OB-RGRP). Yeast cells with a disrupted VPS55 present normal vacuolar morphology, but exhibit an abnormal secretion of the Golgi form of the soluble vacuolar carboxypeptidase Y. However, trafficking of the membrane-bound vacuolar… CONTINUE READING

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