Yeast Uri1p promotes translation initiation and may provide a link to cotranslational quality control.

@article{Deplazes2009YeastUP,
  title={Yeast Uri1p promotes translation initiation and may provide a link to cotranslational quality control.},
  author={Anna Deplazes and Natalie M{\"o}ckli and Brian Luke and Daniel Auerbach and Matthias Peter},
  journal={The EMBO journal},
  year={2009},
  volume={28 10},
  pages={1429-41}
}
Translation initiation in eukaryotes is accomplished by a large set of translation initiation factors, some of which are regulated by signals monitoring intracellular and environmental conditions. Here, we show that Uri1p is required for efficient translation initiation in budding yeast. Indeed, uri1Delta cells are slow growing, sensitive to translation inhibitors and they exhibit an increased 80S peak in polysome profiles. Moreover, GCN4 translation is derepressed in uri1Delta cells, strongly… CONTINUE READING

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