Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking

@article{Yin2006YeastSR,
  title={Yeast Ste2 receptors as tools for study of mammalian protein kinases and adaptors involved in receptor trafficking},
  author={Dezhong Yin and Elena Shumay and Hsien-yu Wang and Craig C. Malbon},
  journal={Journal of Molecular Signaling},
  year={2006},
  volume={1},
  pages={2 - 2}
}
BACKGROUND Mammalian receptors that couple to effectors via heterotrimeric G proteins (e.g., beta 2-adrenergic receptors) and receptors with intrinsic tyrosine kinase activity (e.g., insulin and IGF-I receptors) constitute the proximal points of two dominant cell signaling pathways. Receptors coupled to G proteins can be substrates for tyrosine kinases, integrating signals from both pathways. Yeast cells, in contrast, display G protein-coupled receptors (e.g., alpha-factor pheromone receptor… CONTINUE READING
BETA

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