Yeast Sco1, a protein essential for cytochrome c oxidase function is a Cu(I)-binding protein.

@article{Nittis2001YeastSA,
  title={Yeast Sco1, a protein essential for cytochrome c oxidase function is a Cu(I)-binding protein.},
  author={T Nittis and Graham N George and Dennis R Winge},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 45},
  pages={42520-6}
}
Sco1 is a conserved essential protein, which has been implicated in the delivery of copper to cytochrome c oxidase, the last enzyme of the electron transport chain. In this study, we show for the first time that the purified C-terminal domain of yeast Sco1 binds one Cu(I)/monomer. X-ray absorption spectroscopy suggests that the Cu(I) is ligated via three ligands, and we show that two cysteines, present in a conserved motif CXXXC, and a conserved histidine are involved in Cu(I) ligation. The… CONTINUE READING

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