Yeast SAS silencing genes and human genes associated with AML and HIV–1 Tat interactions are homologous with acetyltransferases

@article{Reifsnyder1996YeastSS,
  title={Yeast SAS silencing genes and human genes associated with AML and HIV–1 Tat interactions are homologous with acetyltransferases},
  author={Cheryl Reifsnyder and Joanna E. Lowell and Astrid S Clarke and Lorraine Pillus},
  journal={Nature Genetics},
  year={1996},
  volume={14},
  pages={42-49}
}
Silencing is an epigenetic form of transcriptional regulation whereby genes are heritably, but not necessarily permanently, inactivated. We have identified the Saccharomyces cerevisiae genes SAS2 and SAS3 through a screen for enhancers of sir1 epigenetic silencing defects. SAS2, SAS3 and a Schizosaccharomyces pombe homologue are closely related to several human genes, including one associated with acute myeloid leukaemia arising from the recurrent translocation t(8;16)(p11;p13) and one… CONTINUE READING
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