Yeast N-glycanase distinguishes between native and non-native glycoproteins.

@article{Hirsch2004YeastND,
  title={Yeast N-glycanase distinguishes between native and non-native glycoproteins.},
  author={Christian Hirsch and Shahram Misaghi and Dani{\"e}l Blom and Michael E Pacold and Hidde L. Ploegh},
  journal={EMBO reports},
  year={2004},
  volume={5 2},
  pages={201-6}
}
N-glycanase from Saccharomyces cerevisiae (Png1) preferentially removes N-glycans from misfolded proteins. The ability of Png1 to distinguish between folded and misfolded glycoproteins is reminiscent of substrate recognition by UDP-glucose glycoprotein glucosyl transferase, an enzyme that possesses this trait. The only known in vivo substrates of Png1 are aberrant glycoproteins that originate in the endoplasmic reticulum, and arrive in the cytoplasm for proteasomal degradation. The substrate… CONTINUE READING

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