Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.

@article{Prakash2009YeastMH,
  title={Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.},
  author={R Udaya Prakash and Dominik Satory and Elo{\"i}se Dray and Almas Papusha and J{\"u}rgen Scheller and Wilfried Kramer and Lumir Krejci and Hannah W. Klein and James E Haber and Patrick M. Sung and Grzegorz Ira},
  journal={Genes & development},
  year={2009},
  volume={23 1},
  pages={
          67-79
        }
}
Eukaryotes possess mechanisms to limit crossing over during homologous recombination, thus avoiding possible chromosomal rearrangements. We show here that budding yeast Mph1, an ortholog of human FancM helicase, utilizes its helicase activity to suppress spontaneous unequal sister chromatid exchanges and DNA double-strand break-induced chromosome crossovers. Since the efficiency and kinetics of break repair are unaffected, Mph1 appears to channel repair intermediates into a noncrossover pathway… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 112 CITATIONS, ESTIMATED 64% COVERAGE

Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1.

  • Genes & development
  • 2016
VIEW 17 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

DNA damage tolerance in mammalian cells

VIEW 30 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2009
2019

CITATION STATISTICS

  • 21 Highly Influenced Citations

  • Averaged 6 Citations per year from 2017 through 2019