Yeast Mannans inhibit binding and phagocytosis of zymosan by mouse peritoneal macrophages

@article{Sung1983YeastMI,
  title={Yeast Mannans inhibit binding and phagocytosis of zymosan by mouse peritoneal macrophages},
  author={SJ Sung and R B Nelson and S Silverstein},
  journal={The Journal of Cell Biology},
  year={1983},
  volume={96},
  pages={160 - 166}
}
We have examined the effects of various mannans, glycoproteins, oligosaccharides, monosaccharides, and sugar phosphates on the binding and phagocytosis of yeast cell walls (zymosan) by mouse peritoneal macrophages. A phosphonomannan (PO(4):mannose ratio = 1:8:6) from kloeckera brevis was the most potent inhibitor tested; it inhibited binding and phagocytosis by 50 percent at concentrations of approximately 3-5 mug/ml and 10 mug/ml, respectively. Removal of the phosphate from this mannan by mild… CONTINUE READING
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Genetics of ycast malmoprotein biosynthesis

  • C. E. Ballou
  • editors. American Chemical Society,
  • 1980
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