Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

@article{Steffen2008YeastLS,
  title={Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4},
  author={Kristan K. Steffen and Vivian L Mackay and Emily O. Kerr and Mitsuhiro Tsuchiya and Di Hu and Lindsay A. Fox and Nick Dang and Elijah D. Johnston and Jonathan A. Oakes and Bie Nga Tchao and Diana N. Pak and Stanley Fields and Brian Kennedy and Matt Kaeberlein},
  journal={Cell},
  year={2008},
  volume={133},
  pages={292-302}
}
In nearly every organism studied, reduced caloric intake extends life span. In yeast, span extension from dietary restriction is thought to be mediated by the highly conserved, nutrient-responsive target of rapamycin (TOR), protein kinase A (PKA), and Sch9 kinases. These kinases coordinately regulate various cellular processes including stress responses, protein turnover, cell growth, and ribosome biogenesis. Here we show that a specific reduction of 60S ribosomal subunit levels slows aging in… CONTINUE READING
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