Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity.

@article{Carmen1999YeastHF,
  title={Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity.},
  author={Andrew A. Carmen and Patrick R. Griffin and Jimmy R. Calaycay and Stephen E. Rundlett and Yuko Suka and Michael R. Grunstein},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 22},
  pages={12356-61}
}
Histone deacetylases such as human HDAC1 and yeast RPD3 are trichostatin A (TSA)-sensitive enzymes that are members of large, multiprotein complexes. These contain specialized subunits that help target the catalytic protein to histones at the appropriate DNA regulatory element, where the enzyme represses transcription. To date, no deacetylase catalytic subunits have been shown to have intrinsic activity, suggesting that noncatalytic subunits of the deacetylase complex are required for their… CONTINUE READING