Yeast-Derived Particulate β-Glucan Treatment Subverts the Suppression of Myeloid-Derived Suppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSC Differentiation to APC in Cancer.

@article{Albeituni2016YeastDerivedP,
  title={Yeast-Derived Particulate β-Glucan Treatment Subverts the Suppression of Myeloid-Derived Suppressor Cells (MDSC) by Inducing Polymorphonuclear MDSC Apoptosis and Monocytic MDSC Differentiation to APC in Cancer.},
  author={Sabrin H Albeituni and Chuanlin Ding and Min Liu and Xiaoling Hu and Fengling Luo and Goetz H. Kloecker and Michael Bousamra and Huang-ge Zhang and Jun Yan},
  journal={Journal of immunology},
  year={2016},
  volume={196 5},
  pages={
          2167-80
        }
}
  • Sabrin H Albeituni, Chuanlin Ding, +6 authors Jun Yan
  • Published in Journal of immunology 2016
  • Biology, Medicine
  • Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells that promote tumor progression. In this study, we demonstrated that activation of a C-type lectin receptor, dectin-1, in MDSC differentially modulates the function of different MDSC subsets. Yeast-derived whole β-glucan particles (WGP; a ligand to engage and activate dectin-1, oral treatment in vivo) significantly decreased tumor weight and splenomegaly in tumor-bearing mice with reduced… CONTINUE READING

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