Yeast DNA topoisomerase II is encoded by a single-copy, essential gene.

@article{Goto1984YeastDT,
  title={Yeast DNA topoisomerase II is encoded by a single-copy, essential gene.},
  author={Takeshi Goto and James Chunjay Wang},
  journal={Cell},
  year={1984},
  volume={36 4},
  pages={1073-80}
}
The gene TOP2 encoding yeast topoisomerase II has been cloned by immunological screening of a yeast genomic library constructed in the phage lambda expression vector, lambda gt11. The ends of the message encoded by the cloned DNA fragment were delimited by the Berk and Sharp procedure (S1 nuclease mapping) for the 5' end and mapping of the polyA tail portion of a cDNA fragment for the 3' end. The predicted size of the message agrees with the length of the message as determined by Northern blot… CONTINUE READING

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