Yeast DNA ligase IV mediates non-homologous DNA end joining

  title={Yeast DNA ligase IV mediates non-homologous DNA end joining},
  author={T. Wilson and U. Grawunder and M. Lieber},
  • T. Wilson, U. Grawunder, M. Lieber
  • Published 1997
  • Biology, Medicine
  • Nature
  • The discovery of homologues from the yeast Saccharomyces cerevisiae of the human Ku DNA-end-binding proteins (HDF1 and KU80) has established that this organism is capable of non-homologous double-strand end joining (NHEJ), a form of DNA double-strand break repair (DSBR) active in mammalian V(D)J recombination. Identification of the DNA ligase that mediates NHEJ in yeast will help elucidate the function of the four mammalian DNA ligases in DSBR, V(D)J recombination and other reactions. Here we… CONTINUE READING
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