Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers

@article{Yan2008YeastBA,
  title={Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers},
  author={Zhun Yan and Michael Costanzo and Lawrence E. Heisler and Jadine Paw and Fiona Kaper and Brenda J. Andrews and Charles Boone and Guri Giaever and Corey Nislow},
  journal={Nature Methods},
  year={2008},
  volume={5},
  pages={719-725}
}
The ability to perform complex bioassays in parallel enables experiments that are otherwise impossible because of throughput and cost constraints. For example, highly parallel chemical-genetic screens using pooled collections of thousands of defined Saccharomyces cerevisiae gene deletion strains are feasible because each strain is bar-coded with unique DNA sequences. It is, however, time-consuming and expensive to individually bar-code individual strains. To provide a simple and general method… CONTINUE READING