Year : 2010 Cone versus rod disease in a mutant Rpgr mouse caused by different genetic

Abstract

PURPOSE. To establish mouse models for RPGR-associated diseases by generating and characterizing an Rpgr mutation (inframe deletion of exon 4) in two different genetic backgrounds(BL/6 and BALB/c). METHODS. Gene targeting in embryonic stem (ES) cells was performed to introduce a in-frame deletion of exon 4 in the Rpgr gene (RpgrEx4). Subsequently, the… (More)

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