Year : 2004 Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic

@inproceedings{Greeve2004Year2,
  title={Year : 2004 Age-dependent neurodegeneration and Alzheimer-amyloid plaque formation in transgenic},
  author={Isabell Greeve and Doris Kretzschmar and Jakob-Andreas Tsch{\"a}pe and Anika Beyn and Claire Brellinger and Michaela Schweizer and Roger M. Nitsch and Rita Reifegerste},
  year={2004}
}
Beta-amyloid peptides that are cleaved from the amyloid precursor protein (APP) play a critical role in Alzheimer's disease (AD) pathophysiology. Here, we show that in Drosophila, the targeted expression of the key genes of AD, APP, the beta-site APP-cleaving enzyme BACE, and the presenilins led to the generation of beta-amyloid plaques and age-dependent neurodegeneration as well as to semilethality, a shortened life span, and defects in wing vein development. Genetic manipulations or… CONTINUE READING

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