Year : 2000 Mice with combined gene knockouts reveal essential and partially redundant functions of amyloid precursor protein family members

@inproceedings{Heber2006Year2,
  title={Year : 2000 Mice with combined gene knockouts reveal essential and partially redundant functions of amyloid precursor protein family members},
  author={Sabine Heber and Jochen Herms and Vladan Gajic and J Weis Und J Hainfellner and Adriano Aguzzi and Thomas R{\"u}licke and Hans Kretzschmar and Cornelia S. von Koch and Sangram S. Sisodia and Phillippe Tremml and Hans-Peter Lipp and David P Wolfer and Ulrike K. M{\"u}ller},
  year={2006}
}
The amyloid precursor protein (APP) involved in Alzheimer's disease is a member of a larger gene family including amyloid precursor-like proteins APLP1 and APLP2. We generated and examined the phenotypes of mice lacking individual or all possible combinations of APP family members to assess potential functional redundancies within the gene family. Mice deficient for the nervous system-specific APLP1 protein showed a postnatal growth deficit as the only obvious abnormality. In contrast to this… CONTINUE READING
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