Yb(OTf)3-Mediated Access to Furans from β-Ketothioamides via Eschenmoser Sulfide Contraction Reaction.

@article{Li2015YbOTf3MediatedAT,
  title={Yb(OTf)3-Mediated Access to Furans from β-Ketothioamides via Eschenmoser Sulfide Contraction Reaction.},
  author={Ming Li and Xiang-Jing Kong and Li-Rong Wen},
  journal={The Journal of organic chemistry},
  year={2015},
  volume={80 24},
  pages={
          11999-2005
        }
}
A mild and straightforward synthetic protocol for construction of a furan skeleton promoted by Yb(OTf)3 from β-ketothioamides and arylglyoxals has been developed at room temperature. Importantly, this protocol involves a tandem sequence that includes aldol condensation, N-cyclization, ring opening, O-cyclization, S-cyclization, and Eschenmoser sulfide contraction. 

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