Yas3p, an Opi1 family transcription factor, regulates cytochrome P450 expression in response to n-alkanes in Yarrowia lipolytica.

@article{Hirakawa2009Yas3pAO,
  title={Yas3p, an Opi1 family transcription factor, regulates cytochrome P450 expression in response to n-alkanes in Yarrowia lipolytica.},
  author={Kiyoshi Hirakawa and Satoshi Kobayashi and Takuro Inoue and Setsu Endoh-Yamagami and Ryouichi Fukuda and Akinori Ohta},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 11},
  pages={7126-37}
}
In the alkane-assimilating yeast Yarrowia lipolytica, the expression of ALK1, a gene encoding cytochrome P450 that catalyzes the first step of n-alkane oxidation, is induced by n-alkanes. We previously demonstrated that two basic helix-loop-helix proteins, Yas1p and Yas2p, activate the transcription of ALK1 in an alkane-dependent manner by forming a heterocomplex and binding to alkane-responsive element 1 (ARE1), a cis-acting element in the ALK1 promoter. Here we identified an Opi1 family… CONTINUE READING