Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair.

@article{Deng2016Yap1RM,
  title={Yap1 Regulates Multiple Steps of Chondrocyte Differentiation during Skeletal Development and Bone Repair.},
  author={Yujie Deng and Ailing Wu and Pikshan Li and Gang Li and Ling Qin and Hai Han Song and Kinglun Kingston Mak},
  journal={Cell reports},
  year={2016},
  volume={14 9},
  pages={2224-2237}
}
Hippo signaling controls organ size and tissue regeneration in many organs, but its roles in chondrocyte differentiation and bone repair remain elusive. Here, we demonstrate that Yap1, an effector of Hippo pathway inhibits skeletal development, postnatal growth, and bone repair. We show that Yap1 regulates chondrocyte differentiation at multiple steps in which it promotes early chondrocyte proliferation but inhibits subsequent chondrocyte maturation both in vitro and in vivo. Mechanistically… CONTINUE READING
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