Yap1, transcription regulator in the Hippo signaling pathway, is required for Xenopus limb bud regeneration.


The Hippo signaling pathway is conserved from insects to mammals and is important for multiple processes, including cell proliferation, apoptosis and tissue homeostasis. Hippo signaling is also crucial for regeneration, including intercalary regeneration, of the whole body in the flatworm and of the leg in the cricket. However, its role in vertebrate… (More)
DOI: 10.1016/j.ydbio.2014.01.018