Yap suppresses T-cell function and infiltration in the tumor microenvironment

  title={Yap suppresses T-cell function and infiltration in the tumor microenvironment},
  author={Eleni Stampouloglou and Nan Cheng and A. Federico and Emily Slaby and Stephano Monti and Gregory L Szeto and X. Varelas},
  journal={PLoS Biology},
  • Eleni Stampouloglou, Nan Cheng, +4 authors X. Varelas
  • Published 2020
  • Biology, Medicine
  • PLoS Biology
  • A major challenge for cancer immunotherapy is sustaining T-cell activation and recruitment in immunosuppressive solid tumors. Here, we report that the levels of the Hippo pathway effector Yes-associated protein (Yap) are sharply induced upon the activation of cluster of differentiation 4 (CD4)-positive and cluster of differentiation 8 (CD8)-positive T cells and that Yap functions as an immunosuppressive factor and inhibitor of effector differentiation. Loss of Yap in T cells results in enhanced… CONTINUE READING
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