Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development

@inproceedings{Reginensi2013YapAC,
  title={Yap- and Cdc42-Dependent Nephrogenesis and Morphogenesis during Mouse Kidney Development},
  author={Antoine Reginensi and Rizaldy P Scott and Alex Gregorieff and Mazdak Bagherie-Lachidan and Chaeuk Chung and Dae-sik Lim and Tony J. Pawson and Jeff Wrana and Helen McNeill},
  booktitle={PLoS genetics},
  year={2013}
}
Yap is a transcriptional co-activator that regulates cell proliferation and apoptosis downstream of the Hippo kinase pathway. We investigated Yap function during mouse kidney development using a conditional knockout strategy that specifically inactivated Yap within the nephrogenic lineage. We found that Yap is essential for nephron induction and morphogenesis, surprisingly, in a manner independent of regulation of cell proliferation and apoptosis. We used microarray analysis to identify a suite… CONTINUE READING
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