Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells

@article{Liu2008YamanakaFC,
  title={Yamanaka factors critically regulate the developmental signaling network in mouse embryonic stem cells},
  author={Xiaosong Liu and Junji Huang and Taotao Chen and Ying Wang and Shunmei Xin and Jian Kang Li and Gang Pei and Jiuhong Kang},
  journal={Cell Research},
  year={2008},
  volume={18},
  pages={1177-1189}
}
Yamanaka factors (Oct3/4, Sox2, Klf4, c-Myc) are highly expressed in embryonic stem (ES) cells, and their over-expression can induce pluripotency in both mouse and human somatic cells, indicating that these factors regulate the developmental signaling network necessary for ES cell pluripotency. However, systemic analysis of the signaling pathways regulated by Yamanaka factors has not yet been fully described. In this study, we identified the target promoters of endogenous Yamanaka factors on a… CONTINUE READING
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