Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

@article{Tewari1995YamaCPP32AM,
  title={Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase},
  author={Muneesh Tewari and Long T Quan and Karen O'Rourke and Serge Desnoyers and Zhi Cong Zeng and David R Beidler and Guy G. Poirier and Guy Salvesen and Vishva M. Dixit},
  journal={Cell},
  year={1995},
  volume={81},
  pages={801-809}
}
Although the mechanism of mammalian apoptosis has not been elucidated, a protease of the CED-3/ICE family is anticipated to be a component of the death machinery. Several lines of evidence predict that this protease cleaves the death substrate poly(ADP-ribose) polymerase (PARP) to a specific 85 kDa form observed during apoptosis, is inhibitable by the CrmA… CONTINUE READING