Yaba-like disease virus: an alternative replicating poxvirus vector for cancer gene therapy.

@article{Hu2001YabalikeDV,
  title={Yaba-like disease virus: an alternative replicating poxvirus vector for cancer gene therapy.},
  author={Ying Hu and Jong-chan Lee and J Andrea Mccart and Hui Xu and Bernard Moss and Heinsemberg Alexander and David L. Bartlett},
  journal={Journal of virology},
  year={2001},
  volume={75 21},
  pages={
          10300-8
        }
}
Vaccinia virus is being investigated as a replicating vector for tumor-directed gene therapy. However, the majority of cancer patients have preformed immunologic reactivity against vaccinia virus, as a result of smallpox vaccination, which may limit its use as a vector. The Yaba-like disease (YLD) virus was investigated here as an alternative, replicating poxvirus for cancer gene therapy. We have demonstrated that the YLD virus does not cross-react with vaccinia virus antibodies, and it… CONTINUE READING
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