YY1 transcriptional initiator: protein interactions and association with a DNA site containing unpaired strands.

@article{Usheva1996YY1TI,
  title={YY1 transcriptional initiator: protein interactions and association with a DNA site containing unpaired strands.},
  author={Anny Usheva and Thomas E. Shenk},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 24},
  pages={13571-6}
}
The Ying-Yang 1 protein (YY1) DNA-binding site functions as an initiator element at which YY1, transcription factor IIB (TFIIB), and RNA polymerase II sponsor basal transcription from a supercoiled DNA template. We show that TFIIB binds to YY1, stabilizing its interaction with DNA, and YY1 contacts the large subunit of polymerase II, directing it to the initiation site. YY1 directs initiation from linear DNA containing mismatched sequences within its binding site, leading us to infer that… CONTINUE READING