YMDD motif mutations in chronic hepatitis B antiviral treatment naïve patients: a multi-center study.

  title={YMDD motif mutations in chronic hepatitis B antiviral treatment na{\"i}ve patients: a multi-center study.},
  author={You-wen Tan and Guo-hong Ge and Wei Zhao and Jian-he Gan and Yun M. Zhao and Zhi-Lin Niu and Dong-Jun Zhang and Li Chen and Xue-jun Yu and Li-jun Yang},
  journal={The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases},
  volume={16 3},
OBJECTIVE This study aimed to determine the natural prevalence of variants of tyrosine-methionine-aspartic acid-aspartic acid (YMDD) motif in patients with chronic hepatitis B (CHB), and to explore its relation with demographic and clinical features, hepatitis B virus (HBV) genotypes, and HBV DNA levels. METHODS A total of 1,042 antiviral treatment naïve CHB patients (including with lamivudine [LAM]) in the past year were recruited from outpatient and inpatient departments of six centers from… CONTINUE READING
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