YM155, a selective survivin suppressant, inhibits tumor spread and prolongs survival in a spontaneous metastatic model of human triple negative breast cancer.

@article{Yamanaka2011YM155AS,
  title={YM155, a selective survivin suppressant, inhibits tumor spread and prolongs survival in a spontaneous metastatic model of human triple negative breast cancer.},
  author={Kentaro Yamanaka and Mari Nakata and Naoki Kaneko and Hiroshi Fushiki and Aya Kita and Takahito Nakahara and Hiroshi Koutoku and Masao Sasamata},
  journal={International journal of oncology},
  year={2011},
  volume={39 3},
  pages={569-75}
}
Metastatic triple negative breast cancer [TNBC, with negative expression of estrogen and progesterone receptors and no overexpression of HER2/neu (ErbB-2)] remains a major therapeutic challenge because of its poor overall prognosis and lack of optimal targeted therapies. Survivin has been implicated as an important mediator of breast cancer cell growth and dysfunctions in apoptosis, and its expression correlates with a higher incidence of metastases and patient mortality; thus, survivin is an… CONTINUE READING

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