YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.

@article{Nakahara2007YM155AN,
  title={YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.},
  author={Takahito Nakahara and Aya Kita and Kentaro Yamanaka and Masamichi Mori and Nobuaki Amino and Masahiro Takeuchi and Fumiko Tominaga and Shinji Hatakeyama and Isao Kinoyama and Akira Matsuhisa and Masafumi Kudoh and Masao Sasamata},
  journal={Cancer research},
  year={2007},
  volume={67 17},
  pages={
          8014-21
        }
}
Various accumulating evidence suggests that survivin, a member of the inhibitor of apoptosis (IAP) family, plays an important role in drug resistance and cancer cell survival in many types of cancer, including hormone-refractory prostate cancer (HRPC). Here, we characterized YM155, a novel small-molecule survivin suppressant, using a survivin gene promoter activity assay. YM155 suppressed expression of survivin and induced apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nmol/L. In… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 39 REFERENCES

American Association for Cancer cancerres.aacrjournals.org Downloaded from YM155, a Novel Survivin Suppressant www.aacrjournals.org

LM Levasseur, HK Slocum, YM Rustum, WR. Greco
  • Research. on April
  • 2007
VIEW 1 EXCERPT

YM 155 , a novel small - molecule survivin suppressant , induces regression of established human hormone - refractory prostate tumor xenografts

T Nakahara, M Takeuchi, +3 authors A Matsuhisa
  • Cancer Res
  • 2007

Characterization of the organic cation transporter SLC22A16: a doxorubicin importer.

  • Biochemical and biophysical research communications
  • 2005
VIEW 1 EXCERPT