YM-202204, a new antifungal antibiotic produced by marine fungus Phoma sp.

@article{Nagai2002YM202204AN,
  title={YM-202204, a new antifungal antibiotic produced by marine fungus Phoma sp.},
  author={Koji Nagai and Kazuma Kamigiri and Hisao Matsumoto and Yasuhiro Kawano and Masakazu Yamaoka and Hitoshi Shimoi and Masato Watanabe and Ken-ichi Suzuki},
  journal={The Journal of antibiotics},
  year={2002},
  volume={55 12},
  pages={
          1036-41
        }
}
A new antifungal antibiotic, YM-202204 (1), was found in the culture broth of marine fungus Phoma sp. Q60596. The structure of 1 was determined by several spectroscopic experiments as a new lactone compound. This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells. 
The current status of natural products from marine fungi and their potential as anti-infective agents
TLDR
Novel antibacterial, antiviral, antiprotozoal compounds isolated from marine-derived fungi are discussed and their possible roles in disease eradication and the future commercial exploitation is discussed.
Antimicrobial Activity of Phoma Species against Pathogenic Bacteria
TLDR
Investigation of the antibacterial activity of the endophytic fungus deals with an antimicrobial activity of fungi Phoma against human pathogenic bacteria.
Marine Bioactive Compounds against Aspergillus fumigatus: Challenges and Future Prospects
TLDR
This work reviews the marine bioactive compounds that display a bioactivity against A. fumigatus and proposes strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising in vivo antifungal agents with new modes of action.
Isolation and Structure Elucidation of Neofusapyrone from a Marine-derived Fusarium species, and Structural Revision of Fusapyrone and Deoxyfusapyrone
Three polyketides containing a pyrone ring, neofusapyrone, fusapyrone, and deoxyfusapyrone, were isolated from the marine-derived fungus Fusarium sp. FH-146. Their structures were determined by
Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
TLDR
Thirty-five bacterial and 12 fungal genera associated with sponges that produce antimicrobials were identified, with Streptomyces, Pseudovibrio, Bacillus, Aspergillus and Penicillium as the prominent producers of antimicrobial compounds.
Antifungal potential of marine natural products.
Recent Status and Advancements in the development of Antifungal Agents: Highlights on Plant and Marine Based Antifungals.
TLDR
The renewed interest in plant and marine derived compounds for the fungal diseases created a new way to treat these resistant strains which is evident from the numerous literature publications in recent years.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Dactylfungins, novel antifungal antibiotics produced by Dactylaria parvispora.
TLDR
Novel antifungal antibiotics, designated as dactylfungins A and B, were isolated from the culture broth of Dactylaria parvispora D500, which conjoined with a polyalcohol moiety and a long side chain, based on NMR spectral analyses.
Biological characterization of fusapyrone and deoxyfusapyrone, two bioactive secondary metabolites of Fusarium semitectum.
TLDR
Two alpha-pyrones originally isolated from rice cultures of Fusarium semitectum appear to be potential candidates for biotechnological applications, as well as good models for studies on mechanism(s) of action and structure-activity relationships.
Molecular breeding of yeast with higher metal-adsorption capacity by expression of histidine-repeat insertion in the protein anchored to the cell wall.
TLDR
A fusion protein of hexa-histidine repeat (His) and glycosylphosphatidylinositol (GPI)-anchor region of Saccharomyces cerevisiae Cwp1 with Aspergillus oryzae Taka-amylase A (TAA) was expressed on the yeast cell surface and demonstrated amylolytic activity.
Sed1p Is a Major Cell Wall Protein ofSaccharomyces cerevisiae in the Stationary Phase and Is Involved in Lytic Enzyme Resistance
TLDR
Results indicate that Sed1p is a major structural cell wall protein in stationary-phase cells and is required for lytic enzyme resistance.
Identification of a species‐specific inhibitor of glycosylphosphatidylinositol synthesis
TLDR
The results suggest that despite the conserved core structure, the GPI biosynthetic machinery may be different enough between mammalian and protozoa to represent a target for anti‐protozoan chemotherapy.
Studies on the distribution of alkalophilic and alkali-tolerant soil fungi I
TLDR
Ability to grow under alkaline conditions, as well as under acidic conditions, was common in many Acremonium species, suggesting the use of alkaline medium facilitates the isolation of alkalophilic soil fungi.
A conditionally lethal yeast mutant blocked at the first step in glycosyl phosphatidylinositol anchor synthesis.
TLDR
The gpi1 mutant is defective in vitro in the synthesis of N-acetylglucosaminyl phosphatidylinositol, the first intermediate in GPI synthesis, and is also temperature-sensitive for growth and could be exploited as a target for antifungal or antiparasitic agents.
Temperature-sensitive Yeast GPI Anchoring Mutants gpi2 and gpi3 Are Defective in the Synthesis of N-Acetylglucosaminyl Phosphatidylinositol.
TLDR
Two more conditionally lethal mutants are reported, gpi2 and gpi3, which, like gpi1, have a temperature-sensitive defect in the incorporation of [3H]inositol into protein and which lack in vitro GlcNAc-phosphatidyl inositol synthetic activity.
Site-directed mutagenesis of catalytic active-site residues of Taka-amylase A.
TLDR
The cDNA encoding Taka-amylase A (EC.3.2.1, TAA) was isolated to identify functional amino acid residues of TAA by protein engineering and found that the mutant TAA with alteration of Asp206, Glu230, or Asp297 in the putative catalytic site had no alpha-amymylase activity, while that with alterations of Lys209 in thePutative binding site to Arg or Phe had reduced activity.
...
1
2
...