YM-202204, a new antifungal antibiotic produced by marine fungus Phoma sp.

@article{Nagai2002YM202204AN,
  title={YM-202204, a new antifungal antibiotic produced by marine fungus Phoma sp.},
  author={Koji Nagai and Kazuma Kamigiri and Hisao Matsumoto and Yasuhiro Kawano and Masakazu Yamaoka and Hitoshi Shimoi and Masato Watanabe and Ken-ichi Suzuki},
  journal={The Journal of antibiotics},
  year={2002},
  volume={55 12},
  pages={
          1036-41
        }
}
A new antifungal antibiotic, YM-202204 (1), was found in the culture broth of marine fungus Phoma sp. Q60596. The structure of 1 was determined by several spectroscopic experiments as a new lactone compound. This antibiotic exhibited potent antifungal activities against Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus, and also inhibited glycosyl-phosphatidyl-inositol (GPI)-anchoring in yeast cells. 
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The current status of natural products from marine fungi and their potential as anti-infective agents
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Novel antibacterial, antiviral, antiprotozoal compounds isolated from marine-derived fungi are discussed and their possible roles in disease eradication and the future commercial exploitation is discussed.
Novel neofusapyrones isolated from Verticillium dahliae as potent antifungal substances.
Antimicrobial Activity of Phoma Species against Pathogenic Bacteria
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Investigation of the antibacterial activity of the endophytic fungus deals with an antimicrobial activity of fungi Phoma against human pathogenic bacteria.
Pyronepolyene C-glucosides with NF-κB inhibitory and anti-influenza A viral (H1N1) activities from the sponge-associated fungus Epicoccum sp. JJY40.
BIOACTIVE METABOLITES FROM MARINE MICROORGANISMS
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This work reviews the marine bioactive compounds that display a bioactivity against A. fumigatus and proposes strategies that could speed up an efficient discovery and broaden the dimensions of screening in order to obtain promising in vivo antifungal agents with new modes of action.
Isolation and Structure Elucidation of Neofusapyrone from a Marine-derived Fusarium species, and Structural Revision of Fusapyrone and Deoxyfusapyrone
Three polyketides containing a pyrone ring, neofusapyrone, fusapyrone, and deoxyfusapyrone, were isolated from the marine-derived fungus Fusarium sp. FH-146. Their structures were determined by…
Bioprospecting Sponge-Associated Microbes for Antimicrobial Compounds
TLDR
Thirty-five bacterial and 12 fungal genera associated with sponges that produce antimicrobials were identified, with Streptomyces, Pseudovibrio, Bacillus, Aspergillus and Penicillium as the prominent producers of antimicrobial compounds.
Antifungal potential of marine natural products.
Recent Status and Advancements in the development of Antifungal Agents: Highlights on Plant and Marine Based Antifungals.
TLDR
The renewed interest in plant and marine derived compounds for the fungal diseases created a new way to treat these resistant strains which is evident from the numerous literature publications in recent years.
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