YM-193221, a novel antifungal antibiotic produced by Pseudallescheria ellipsoidea.

  title={YM-193221, a novel antifungal antibiotic produced by Pseudallescheria ellipsoidea.},
  author={Kazuma Kamigiri and Kouichi Tanaka and Hisao Matsumoto and Koji Nagai and Masato Watanabe and Ken-ichi Suzuki},
  journal={The Journal of antibiotics},
  volume={57 9},
A novel antifungal antibiotic, YM-193221, was found in the culture broth of a fungus, Pseudallescheria ellipsoidea. The structure of the antibiotic was determined through several spectroscopic experiments as 2-dimethylamino-1-(4-hydroxyphenyl)-8,10-dimethyl-6-dodecene-3-one. YM-193221 exhibited potent antifungal activity against Candida albicans and also inhibited mannan synthesis in the yeast cell wall. 
9 Citations
Pseudellones A-C, Three Alkaloids from the Marine-Derived Fungus Pseudallescheria ellipsoidea F42-3.
Pseudellones A and B (1 and 2), a pair of irregularly bridged epimonothiodiketopiperazine diastereomers constructed from unusual 3-indolylglycine and alanine residues, and an alkaloid pseudellone C
Scedosporium and Pseudallescheria low molecular weight metabolites revealed by database search
The potential of mMass software search tool with new compound libraries was demonstrated on metabolomics of Scedosporium prolificans, S. apiospermum and Pseudallescheria boydii sensu stricto using accurate matrix‐assisted laser desorption/ionisation mass spectral data of intact fungal spores.
Proteomic analysis of the secretions of Pseudallescheria boydii, a human fungal pathogen with unknown genome.
It is shown that mycelial cells of P. boydii were able to actively secrete proteins into the extracellular environment; some of them were recognized by antibodies present in the serum of a patient with pseudallescheriosis and provided important new perspectives on the biology of this intriguing fungus.
Detection of potential volatile inhibitory compounds produced by endobacteria with biocontrol properties towards Fusarium oxysporum f. sp. cubense race 4
Observations strongly suggest the antifungal nature of the three volatile compounds towards FocR4, which may be attributed to the presence of single compounds such as 2-pentane 3-methyl, methanethiol and 3-undecene.
Proteomics as a Tool to Identify New Targets Against Aspergillus and Scedosporium in the Context of Cystic Fibrosis
Proteomics-based information was collated relating to secreted and cell wall proteins with potential medical applications from the most common filamentous fungi in CF, i.e., Aspergillus and Scedosporium/Lomentospora species, and proteins mentioned may be promising candidates for developing innovative diagnostic and therapeutic tools for fungal infections in CF patients.
Antimicrobial agents : bacterial / fungal Non typhoid salmonellosis : the Israeli experience and review of the literature 563
  • Biology, Medicine
  • 2005
Genome-wide expression profiling reveals genes associated with amphotericin B and fluconazole resistance in experimentally induced antifungal resistant isolates of Candida albicans in experiments conducted at the Centers for Disease Control and Prevention and the Food and Drug Administration.


Mode of action of antifungal agents
This symposium volume surveys the cellular and biochemical mechanisms by which antifungal agents and drugs prevent and counteract diseases caused by fungi. Both plants and animals are susceptible to
Chemical and immunological characterization of the extracellular galactomannan of Aspergillus fumigatus
The galactomannan produced extracellularly by Aspergillus fumigatus has been purified by a double sequential hydrazine-nitrous acid treatment of the ethanol precipitate of the culture filtrate to study the immunoreactivity of GM and HCl-hydrolyzed GM.
Proliferation of Intracellular Structure Corresponding to Reduced Affinity of Fluconazole for Cytochrome P‐450 in Two Low‐Susceptibility Strains of Candida albicans Isolated from a Japanese AIDS Patient
Characteristics related to cytochrome P‐450 (CYP), especially sterol 14α‐demethylase encoded by the ERG11 gene which is the target molecule for fluconazole, are examined, finding the development of mesh membrane structures of the endoplasmic reticula, which is a location related to sterol synthesis, was the most prominent finding.
Effect of tunicamycin treatment on the adherence of Candida albicans to human buccal epithelial cells
The work described here represents an alternative approach to the identification of the yeast ligand and suggests that yeast mannoprotein is of primary importance in the interaction with buccal epithelial cells.
The second capsule gene of cryptococcus neoformans, CAP64, is essential for virulence
This study confirms the previous molecular genetic evidence that capsule is an essential factor for the virulence of C. neoformans in the murine model.
Yeast glycosylation mutants are sensitive to aminoglycosides.
  • N. Dean
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1995
It is suggested that a molecule which prevents the uptake or mediates removal of aminoglycosides requires glycosylation for its activity, and this finding on drug sensitivity provides the most powerful screen to date to identify mutants and thereby to isolate genes involved in all aspects of N-linked gly cosylation.
OCH1 encodes a novel membrane bound mannosyltransferase: outer chain elongation of asparagine‐linked oligosaccharides.
The OCH1 gene was found to encode a novel mannosyltransferase which specifically transfers [14C]mannose to the unique acceptor, the core‐like oligosaccharide of cell wall mannan accumulated in the och1 disruptant.
Adherence and receptor relationships of Candida albicans.
It is shown that mutants lacking CR3 activity are less adherent in vitro and, in fact, less virulent, and that the ligand recognized by the CR3 receptor (C3bi) as well as anti-CR3 antibodies blocks adherence of the organism to endothelial cells.
Adherence to and damage of endothelial cells by Cryptococcus neoformans in vitro: role of the capsule
Results suggest that acapsular or poorly encapsulated C. neoformans may be the form(s) that escapes from the vasculature during initiation of hematogenously disseminated disease.
Molecular basis of cell integrity and morphogenesis in Saccharomyces cerevisiae.
An overall view of the current understanding of cell wall dynamics and of the complex network that controls polarized growth at particular stages of the budding yeast cell cycle and life cycle is offered.