YM-193221, a Novel Antifungal Antibiotic Produced by Pseudallescheria ellipsoidea.

  title={YM-193221, a Novel Antifungal Antibiotic Produced by Pseudallescheria ellipsoidea.},
  author={Kazuma Kamigiri and Kouichi Tanaka and Hisao Matsumoto and Koji Nagai and Masato Watanabe and Ken-ichi Suzuki},
The secreted polyketide boydone A is responsible for the anti‐Staphylococcus aureus activity of Scedosporium boydii
Results suggest that this six‐membered cyclic polyketide could be one of the virulence factors of the fungus, and genes involved in the synthesis of this secreted metabolite are currently being identified in order to confirm the role of thispolyketide in pathogenesis.


YM-193221, a novel antifungal antibiotic produced by Pseudallescheria ellipsoidea.
A novel antifungal antibiotic, YM-193221, was found in the culture broth of a fungus, Pseudallescheria ellipsoidea, and exhibited potent antIFungal activity against Candida albicans and also inhibited mannan synthesis in the yeast cell wall.