YM-181741, a novel benz[a]anthraquinone antibiotic with anti-Helicobacter pylori activity from Streptomyces sp.

@article{Taniguchi2002YM181741AN,
  title={YM-181741, a novel benz[a]anthraquinone antibiotic with anti-Helicobacter pylori activity from Streptomyces sp.},
  author={Masatoshi Taniguchi and Koji Nagai and Masato Watanabe and Nami Nimura and Ken-ichi Suzuki and Akihiro Tanaka},
  journal={The Journal of antibiotics},
  year={2002},
  volume={55 1},
  pages={30-5}
}
A novel benz[a]anthraquinone, YM-181741, was isolated from the culture broth of actinomycete strain Q57219. The strain was identified as Streptomyces sp. by morphological and chemotaxonomic characterization. YM-181741 was purified from the culture supernatant by serial column chromatography. The structure of YM-181741 was determined by spectroscopic analysis including one- and two-dimensional NMR experiments. YM-181741 showed selective anti-Helicobacterpylori activity with a MIC value of 0.2… CONTINUE READING