YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model

Abstract

Ewing sarcoma is an aggressive tumor of bone and soft tissue affecting predominantly children and young adults. Tumor-specific chromosomal translocations create EWS-FLI1 and similar aberrant ETS fusion proteins that drive sarcoma development in patients. ETS family fusion proteins and over-expressed ETS proteins are also found in acute myeloid leukemia (AML… (More)
DOI: 10.18632/oncotarget.5520

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