YEARS OF IGF 1 Role of IGF 1 and EFN – EPH signaling in skeletal metabolism

  title={YEARS OF IGF 1 Role of IGF 1 and EFN – EPH signaling in skeletal metabolism},
  author={Jonathan S. Lindsey and John B. Rundle and Sumit Mohan},
Insulin-like growth factor 1(IGF1) and ephrin ligand (EFN)–receptor (EPH) signaling are both crucial for bone cell function and skeletal development and maintenance. IGF1 signaling is the major mediator of growth hormone-induced bone growth, but a host of different signals and factors regulate IGF1 signaling at the systemic and local levels. Disruption of the Igf1 gene results in reduced peak bone mass in both experimental animal models and humans. Additionally, EFN–EPH signaling is a complex… CONTINUE READING


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