YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism.

@article{Caplan1992YDJ1pFP,
  title={YDJ1p facilitates polypeptide translocation across different intracellular membranes by a conserved mechanism.},
  author={Arthur J. Caplan and Douglas M. Cyr and Michael G. Douglas},
  journal={Cell},
  year={1992},
  volume={71 7},
  pages={1143-55}
}
The role of S. cerevisiae YDJ1 protein (YDJ1p) in polypeptide translocation across membranes has been examined. A conditional ydj1 mutant strain (ydj1-151TS) is defective for import of several polypeptides into mitochondria and alpha factor into the endoplasmic reticulum at 37 degrees C. These defects are suppressed by E. coli dnaJ or overexpression of S. cerevisiae SIS1 proteins. A different ydj1 mutant, which cannot be farnesylated (ydj1-S406), displays similar transport defects to the ydj1… CONTINUE READING