YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter.

@article{Holm2002YB1RT,
  title={YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter.},
  author={Per Sonne Holm and Stephan Bergmann and Karsten Jurchott and Hermann Lage and Karsten Brand and A. -M. Ladhoff and Klaus Mantwill and David T. Curiel and Matthias Dobbelstein and Manfred Dietel and Bernd Gansbacher and H Royer},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 12},
  pages={10427-34}
}
The adenovirus early proteins E1A and E1B-55kDa are key regulators of viral DNA replication, and it was thought that targeting of p53 by E1B-55kDa is essential for this process. Here we have identified a previously unrecognized function of E1B for adenovirus replication. We found that E1B-55kDa is involved in targeting the transcription factor YB-1 to the nuclei of adenovirus type 5-infected cells where it is associated with viral inclusion bodies believed to be sites of viral transcription and… CONTINUE READING
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