YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1

Abstract

Under cell stress, global protein synthesis is inhibited to preserve energy. One mechanism is to sequester and silence mRNAs in ribonucleoprotein complexes known as stress granules (SGs), which contain translationally silent mRNAs, preinitiation factors, and RNA-binding proteins. Y-box binding protein 1 (YB-1) localizes to SGs, but its role in SG biology is… (More)
DOI: 10.1083/jcb.201411047

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