YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity.

@article{GimnezBonaf2004YB1IU,
  title={YB-1 is upregulated during prostate cancer tumor progression and increases P-glycoprotein activity.},
  author={Pepita Gim{\'e}nez-Bonaf{\'e} and Matthew N. Fedoruk and Tanis G Whitmore and Majid Akbari and Jody L Ralph and Susan L. Ettinger and Martin E. Gleave and Colleen C. Nelson},
  journal={The Prostate},
  year={2004},
  volume={59 3},
  pages={337-49}
}
BACKGROUND Currently, the main obstacle to curing advanced prostate cancer is development of androgen independence (AI), where malignant cells acquire the ability to survive in the absence of androgens. Our initial experimental approach used cDNA microarrays to characterize changes in gene expression in the LNCaP human prostate tumor model during progression to AI. The transcription factor Y-box binding protein (YB-1) was shown to be one of the genes upregulated. We focused on increased YB-1… CONTINUE READING